Acute Oral Toxicity Test of Antihypertensive Polyherbal Preparations Containing Allium sativum Curcuma aeruginosa & Amomi fructus

Hypertension is a major factor causing atherosclerotic cardiovascular disease, heart failure, stroke, and kidney failure. Polyherbal preparations containing garlic (Aliium sativum), temu ireng (Curcumae aeruginosae) cardamom (Amomi fructus) have been widely used to treat hypertension. Despite in community, its safety has not evaluated. This study aimed evaluate the single dose oral of polyherbal. The acute toxicity test was done using fixed methods. Single polyherbal administered female Wistar rats. clinical examination after administration continued until 14th day check for symptoms toxicity, changes body weight. On 15, animal sacrificed histopathological conducted. weight did differ between that received However, there an increase group at 2000 mg/kg. absolute relative organs also similar among groups. There were no macroscopic kidney, liver, heart, spleen, aorta, lungs. Aliium sativum, Curcumae aeruginosae Amomi fructus safe with LD50 >2000-5000 mg/kg